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10.1016/j.pbb.2006.09.008 Pharmacol Biochem Behav

Similarly, dysregulation of the PI3KAktFOXO3 axis drives premature awakening of dormant primordial follicles: activating mutations in PIK3CA or loss of PTEN propel unrestrained follicle recruitment, exhausting the reserve [108,109,110]

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Notably, adults without cognitive impairment reporting a bad night's sleep are more likely to show signs of amyloid buildup in their brains observed by PET scans (Spira et al., 2013)